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Technology > IMMC
To address the need for detecting multiple targets in a self-contained, low-cost disposable device, Akonni has developed a proprietary, innovative technology that distinguishes Akonni’s TruArrays from other microarray technologies – the integrated microfluidic microarray consumable (IMMC).
The unique, simple, yet elegant design of Akonni’s IMMCs allow PCR amplification to occur in the 3D Gel Drop Array chamber of the IMMC, eliminating the need for multiple fluidic transfer steps. After the reaction is complete, the amplified product flows into an integrated waste chamber absorbent, virtually eliminating the risk of PCR contamination. This enables the array surface to be washed after amplification and hybridization, while maintaining a closed-amplicon system. The waste chamber and the microarray chamber are separated by a microfluidic stop, which confines the reaction mix to the microarray chamber during thermalcycling.
The microfluidic innovation of this design is that these closed-amplicon microarray devices do not require valves, which are frequently required and utilized in competing PCR-based microfluidic devices. Furthermore, unlike existing competing methods, Akonni’s method IMMC does not require special hydrophobic coatings or treatments. Instead, we have demonstrated that a proprietary design based on geometry and materials confines the liquid reagents in the microarray chamber until an additional reagent, such as a wash solution, is added.
Based on its recent analysis of the microarrays in molecular diagnostics (MDx) market, Frost & Sullivan recognizes Akonni Biosystems with the 2017 North American New Product Innovation Award.
Akonni’s integrated MDx system, TruDiagnosis®, is revolutionizing the point-of-care molecular testing market by enabling target detection from a variety of sample types. TruDiagnosis® is powered by TruArray®, a patented 3D gel-drop microarray technology for sample screening that instantly indicates the presence of disease markers in real time.
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